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This is the peak Two Hours: The coming down wasn't very sharp at all. Also noticed that the snot on my sleeve has dried into white powder Four hours. It’s not very nice but hardly hellish like others have put it. Edgy and agitated, but watching some TV distracts me and makes me feel all right. Likely because the dopamine "feel good" feeling has gone, but the norephinephrine stimulation remains. I am also starting to feel somewhat cold and regretting not taking a jacket when leaving.Before taking methylphenidate, be sure to tell your doctor if you have any of these problems. Pregnancy Category C As a category C medication, methylphenidate may be harmful to an unborn baby. It's an atypical antipsychotic that is a strong antihistamine and dopamine antagonist. In the past I would have taken 50mg of Seroquel at this point.
Although, untreated ADHD has been linked to an increased risk of substance abuse later in life , the likelihood of future drug abuse disorder is actually decreased when ADHD is properly treated .
Still, because methylphenidate is an amphetamine and stimulant, there is the potential for increasing tolerance to the medication over long-term use as well as the danger of abuse.
And this medication is not recommended for people who have a history of drug abuse.
Also I wouldn't be surprised if, a la cocaine, alcohol effects how the methylphenidate is processed and results in more toxic metabolites.
In extreme circumstances you've got to be careful with stims getting cold/hot, the constriction of blood vessels and other factors makes it much more difficult for your body to self regulate its temp while the mental effects make it harder to notice when you're chilling off or over heating.